Biodegradable Sensors for the Brain: Intracranial Pressure Monitor for Traumatic Brain Injury
Newly developed brain sensors have the capability to biodegrade: that is, all the sensor materials dissolves away in cerebrospinal fluid over a controlled time period. Secondary surgery to remove implants becomes unnecessary and a nidus of infection, bleeding, and surgical risk is removed. The sensors’ wireless operation provides a fully implantable brain monitor in real time, eliminating the need for hospital visits for for additional treatment. The pressure sensors have 3D microelectromechanical systems (MEMS) structure exploiting piezoresistivity of Si nanomembranes, flexibility of biodegradable polymer (PLGA), and nano-porous or Mg foil structural materials.
Fully Implantable, Wireless Monitoring System with Near-Field Communication (NFC)
This wireless monitor provides a critically important feature in mobile and real-time monitoring. Here the CPU embedded chip-scale wireless system offers high-speed, digitalized communication with wireless energy and information transfer through near-field electromagnetic coupling of biodegradable metal inductor coils. The miniaturized system is smaller than a dime (U.S. 10-cent coin) and can be implanted in the brain cavity. Various sensor modalities can be integrated with the current NFC system for other types of application such as temperature, pressure, flow rates, pH and glucose sensing and the like.
Conformal, Flexible, Implantable Sensors for the Brain
Soft, flexible and stretchable electronics provide biological conformal contact, delicate measurement and treatment. The demonstration platform in the image shows extremely thin high-performance electronics on the soft substrate offering conformal contact on actual human brain surfaces (from valley to hills). Application of conformal contact electronics ranges from the peripheral nerves, cardiac surface, brain, tumor cells and tissues engineering to wearable and skin-mounted biodevices. Electrophysiological, physical, and chemical sensors can be built in the same manner, and the interfacial structure can be used for other electric stimulators to modulate tissue activity.
Biodegradable, Inorganic Platform for High-Performance RF Components
Inorganic biomaterials provide robust mechanical characteristics and high performance in electronic operation. A clear understanding of the dissolution products and their biocompatibility demonstrates their usability in biomedical devices with degradable features. Studies have demonstrated that we can generate all necessary electronic components − from resistors, diodes, transistors, and capacitors to inductors − with fully biodegradable metal and Si-based semiconductors less than a few micrometer thick, so that all materials can be dissolved away in the body in a few months. Integrating all components lets us provide more complex and advanced electronic circuits for delicate biomedical sensing and treatment.
Biomedical Reliability of Electronics Device Implants–Biochemical Degradation and Biocompatibility
Reliability of implantable medical electronics in biomedicine is critical in patient care. Biomedical reliability considers both electronic devices and biology. The medical device must operate in a controlled-time manner without loss of function or stability, and there are many challenges from mechanical failure, fatigue to biochemical degradation. In addition, biocompatibility is essential for use it in the human body. The images show a very thin Si nanomembrane (< 100 nm) and its degradation in biofluids as well as its compatibility in the cell proliferation test. [The bioresorbable characteristic of Si lets us build fully degradable electronics, but at the same time the electronics must be protected by passive encapsulation to sustain operation. Active encapsulation studies have been made on various types of polymer and i...
Notices & News
(2023-01) Our professor and Se-Hun attended and demonstrated the product at CES 2023.
(2022-11) Jaehwan and Myungkyun won an excellent award at KIM.
(2022-09) Minha won the grand prize at KMRS.
(2022-04) Minha won an excellent award at KIM.
(2022-05) Ji-Woo won an excellent award at Korean bio-chip conference.
(2022-04) Ji-Woo won an excellent award at KIM.
(2022-03) Our professor received an exellent lecture award from SNU.
(2021-11) Kyung-Seob won the excellent award at KCERS november 2021.
(2021-11) Kyung-Seob won the excellent award at KIM november 2021.
(2021-11) Jae-Hwan won the execellent award at KIM, november 2021.
(2021-09) Young-hwan won the first award at creative design fair September 27, 2021.
(2021-04) Jae-Young got the excellent poster award from 2021 spring conference of the Korean Institute of Metals and Materials, 29 April.
(2020-11) Jio got the best poster award from 2020 fall conference of the Korean Cerimic Society, 25 November.
(2020-10) Jae-Young got the excellent oral presentation award in biomaterial session, 2020 fall conference of the Korean Institute of Metals and Materials online, 30 October.
(2020-08) New research results are reported on 'Donga Science' article.
(2020-08) New research project kick-off meeting was held in 6 August.
(2020-03) We hosted webinar about "Advanced Materials for Transient Electronic Devices" presented by MRS Bulletin. You can access recorded webinar at https://mrs.digitellinc.com/mrs/sessions/31814/view
(2020-01) BIE Lab attended 2020 Gordon Research Conference (Robotics/Multifunctional Materials and Structures) in California, 12 January - 24 January. Min-Ha and Kyung-Sub had poster presentations in each session.
(2019-12) All the BIE members shared their research progress for 2019 fall semester wrap-up seminar. After the seminar, we had a BBQ party and played a screen baseball game.
(2019-10) Prof. Kang has been awarded Leading Creative Researchers of 2019 by Seoul National University.
(2019-09) Prof. Kang has been awarded the POSCO Cheongam Science Fellowship.
(2019-08) BIE had a wrap-up dining to celebrate the end of the summer semester in August 30th.
(2019-07) SNU-KIST Joint Research Laboratory opening ceremony was held in 16 July. Department of materials science and engineering professors and KIST researchers attended the ceremony.
(2019-06) BIE had a wrap-up seminar for 19 spring semester in 19 June. After the seminar, we got a special dining for celebrating the end of the semester.
(2019-04) Sung-Geun gave an oral presentation in biomaterial session, 2019 spring conference of the Korean Institute of Metals and Materials in Changwon, 24 April.
(2019-04) BIEL attended 2019 spring conference of the Korean Institute of Metals and Materials in Changwon, 24 April - 26 April.
(2019-04) Prof. Kang delivers an invited talk at 2019 MRS Spring Meeting & Exhibit on Biodegradable and Biocompatible Electronics session on “Bioresorbable Electronics for Minimally Invasive Medical Sensing and Treatment of Nervous System”.
(2019-04) Prof. Kang delivers an invited talk at SPIE Defense Commercial Sensing on Biodegradable Electronics and Sensor session on “Silicon Transient Electronics: Bioresorbable to Hardware-Secure Device”.
(2019-03) Prof. Kang starts a position in Materials Science and Engineering Department at SNU as an assistant professor. We welcome active and passionate students to our group to join our leading research!
Welcome to Bio-Interfaced Electronics Laboratory
We explore real solutions for healthcare issues in modern society through understanding, exploiting and sharing multidisciplinary science and engineering in bioengineering, biology, materials science, chemistry, mechanics, and electronics engineering. We develop and apply biomedical electronics that provide medical diagnosis and treatment to contribute toward these ultimate goals.
We are entering a new age of personalized and customized biomedical care that requires high-quality and convenient care away from the hospital. This new paradigm urges us to provide the essential engineering keywords “Personal”, “Mobile”, and “Real-time”. Bio-interfaced electronics contributes to the realization of this paradigm in medical instruments and tools.
We in the Bio-Interfaced Electronics (BIE) Lab focus on
1. Biodegradable and minimum-invasive implants offering quick, safe medical treatment at complex levels of surgical care, and reducing the need for surgery, 2. Soft and conformal electronics providing interfaces to the human body from skin to organ and allowing carry-on medical electronics, 3. Biomedical device reliability promoting the safe use of recent biomedical devices in terms of time and biomechanical/chemical degradation
2024년 상반기 입학을 위해 인턴연구에 참여를 원하는 분들은 메일로 문의바랍니다. 유기합성 연구분야는 상시 모집 중입니다.
Current research interested in
Biodegradable, minimally invasive implants
Soft and conformal biomedical devices
Biomedical reliability of electronics
Department of Materials Science and Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea
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